The Molecule of Life: Nitric Oxide Learn MoreBuy Now


Kyäni NitroFX™ is a proprietary blend of noni concentrate that has been proven to increase the production of Nitric Oxide (NO). Also known as “The Molecule of Life,” Nitric Oxide repairs, defends, and maintains every cell of the body. Studied extensively by researchers and physicians, Nitric Oxide has been touted as a powerful, health-promoting molecule by tens of thousands of scientific papers.


Built upon the foundation of Kyäni Nitro FX™, Kyäni Nitro Xtreme™ contains even more nitrate from the proprietary blend of Noni concentrate for increased Nitric Oxide (NO) production in the body. In addition, Nitro Xtreme™ contains CoQ10, Magnesium, Zinc, Chromium, and Niacin. Among many other benefits, these additional nutrients also boost the body’s production of Nitric Oxide.

Kyäni Nitro Xtreme™ is specifically designed for the most demanding parts of your day. Whether you’re an athlete, business professional, student, or busy parent, Nitro Xtreme is perfect for increased energy, physical stamina, and mental clarity.


Nitric Oxide: The Molecule of Life

In 1998, three scientists were awarded the Nobel Prize in Physiology of Medicine for their work on Nitric Oxide. Now called “The Molecule of Life,” Nitric Oxide has been shown to positively influence:

Blood Circulation
One of Nitric Oxide’s most important qualities is the ability to dilate the blood vessels, leading to improved circulation and heart health.

Nitric Oxide is a “signaling molecule” with anti-inflammatory effects.

Brain Function
Nitric Oxide is an essential chemical messenger, improving the storage of information and communication between neurons.

Nitric Oxide helps improve motility and microcirculation, promoting blood flow and nutrient delivery throughout the body.

Sexual Function
Nitric Oxide has been shown to naturally increase blood flow, which is essential to improved sexual libido, performance, and satisfaction.

“In my 25 years of research, I have never seen a molecule [like Nitric Oxide] that so pervasively influences normal and abnormal body functions.”
Dr. Solomon Snyder Director of Neuroscience, John Hopkins Medical School




  • Promotes Increased Energy
  • Encourages Blood Flow
  • Helps Improve Circulation
  • Helps Reduce Inflammation
  • Encourages Heart Health
  • Improves Sexual Function
  • Supports Cognitive Function
  • Sustains the Immune System
  • Improves Nutrient Absorption

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

“Nitric Oxide has been extensively proven in thousands of studies to aid every system and cell in the body and has shown dramatic results when used by patients suffering from a wide variety of complaints. I have been recommending the proprietary blend of noni extracts to my patients for several years now with wonderful results.” -Dr. Abbas Qutab, MBBS, DC, PhD, OMD.


Both Nitro FX™ and Nitro Xtreme™ contain Kyäni’s proprietary blend of Noni concentrate for increased Nitric Oxide production. Kyäni Nitro Xtreme™ contains additional components to give your body an extra boost. Research shows that the combination of these five ingredients enhances the production of Nitric Oxide in the body and maximizes the body’s potential to utilize it.


Coenzyme Q10 (CoQ10) is an anti-oxidant produced by the human body. It is required for the basic functioning of cells. CoQ10 helps generate up to 95 percent of the human body’s energy. This molecule also promotes cardiovascular health and improved blood flow. CoQ10 levels are reported to decrease with age and chronic diseases.


Magnesium helps convert carbohydrates, protein, sugars, and fats into energy. It also supports muscle relaxation and contraction as well as nerve transmission. Some studies show that increased magnesium is one of the most effective ways to boost energy. The journal of Nutrition reported that low magnesium levels take a significant toll on the body’s energy supply.


Essential to more than 300 enzymes in the body, zinc plays an important role in maintaining a healthy immune system, energy metabolism, protein synthesis, blood sugar balance, wound healing, and brain function.


Chromium helps turn carbohydrates, proteins, and fats into energy. This essential mineral also helps the body regulate blood sugar levels, maintain heart health, improve the immune system, and encourage lean body mass.


Niacin is an anti-oxidant essential for cellular metabolism. It is involved in over 50 metabolic processes that turn carbohydrates and fats into energy. Niacin also helps maintain heart health, supports the digestive tract, and promotes a healthy nervous system.

“The body can last 5 minutes without oxygen (O2), but can only last 5 seconds without Nitric Oxide (NO). By generating more Nitric Oxide in the body, you achieve peak performance.”
Dr. Abbas Qutab, Head of Kyäni Medical and Scientific Advisory Board.

Kyäni NitroFX and Nitro Xtreme

“Kyäni Nitro FX is a concentrated blend from Noni fruit juice, which has been valued and prized for its benefits for generations.  This small tree in the coffee family grows throughout the tropical regions of the Pacific Ocean, from South East Asia to Australia. The plant blosssoms generally near the sea and gives fruit the whole year round.

Built upon the foundation of Kyäni Nitro FX, Nitro Xtreme contains Niacin (vitamin B3), Chromium and Zinc. It is designed for you – whether you are an athlete, business professional, student or busy parent – for the most demanding time of your day.


Nitro FX™ 56ml bottle label (PDF)
Nitro Xtreme™ 56 ml bottle label (PDF)


The Kyäni Nitro™ white paper is an informative essay written by our Scientific Advisory Board. It contains valuable in-debth research about the health benefits and ingredients of Kyäni Nitro™.

White paper: Kyäni Nitro FX™ and Kyäni Nitro Xtreme™


Nitric Oxide is a simple molecule, made up of one part nitrogen and one part oxygen. Scientists and researchers around the globe have been astonished by the seemingly limitless list of the functions of Nitric Oxide in the body. “In my 25 years of research, I have never seen a molecule that so pervasively influences normal and abnormal body functions,” said Dr. Solomon Snyder, the director of neuroscience at Johns Hopkins Medical School.

Despite the significance of this molecule, Nitric Oxide is relatively unknown outside the medical research community. Nitric Oxide is a highly reactive gas that is naturally produced in the human body. Nitric Oxide is the most important signaling molecule in the body. It affects a wide range of physiological functions including circulation, inflammation, learning and memory, digestion, penile erection, and oxygen release in tissues from red blood cells. It plays a significant role in many important chemical reactions. Sadly, most people are deficient in the natural production of Nitric Oxide required to maintain optimal health. With today’s fast-paced lifestyle and factors like lack of exercise, poor diet, soil mineral depletion, cigarette smoke, and other air pollutants, the need for higher levels of Nitric Oxide in humans is of critical importance.

Scientifically speaking, Nitric Oxide can be produced in the body through the process of converting L-arginine (one of the 20 amino acids) into citrulline. However, more and more research suggests that L-arginine has potentially negative side effects. Additionally, many co-factors are required to convert L-arginine into Nitric Oxide. Alternatively, Nitric Oxide can be produced more efficiently from substances know as nitrates and nitrites found in plants like Morinda Citrofolia (noni).

During 1999 and 2000, Dr. Thomas Burke and his researchers at Integrated Systems Physiology, an independent lab in Denver, Colorado, conducted in vitro experiments. They tested diluted noni juice on endothelial cells, the cells that line the inner surface of blood vessels proving that noni fruit juice created Nitric Oxide! Their findings suddenly helped to explain the enormous benefits people were seeing from their consumption of noni juice.

Having isolated the main mechanism by which noni works in the body, Kyäni Nitro FX™ and Kyäni Nitro Xtreme™ were developed. Using a proprietary blend of noni concentrate, these extraordinary products utilize groundbreaking research to unlock the secret of noni.

“In my 25 years of research, I have never seen a molecule [like Nitric Oxide] that so pervasively influences normal and abnormal body functions.”
-Dr. Solomon Snyder, Director of Neuroscience, John Hopkins Medical School


Nitric Oxide positively affects nearly every system in the body, promoting better health and wellness. Well-documented as a vasodilator, Nitric Oxide dilates the blood vessels, resulting in improved cardiovascular health. But that’s just the beginning. Look at how many more ways Nitric Oxide can benefit the human body…

Help cells burn more fat
Promotes wound healing
Reduces pain
Encourages lung health
Inhibits viruses and bacteria
Improves digestive function
Provides restful sleep
Maintains healthy blood sugar levels

Fact: If you cut off the oxygen to the heart, the heart will suffer irreversible damage or cell death in 5-7 minutes. If you terminate nitric oxide, it takes only 10-15 seconds.


McKnight, et al. “Chemical Synthesis of Nitric Oxide in the stomach from dietary nitrate in humans.”
Gut. 1997 Feb; 40 (2):211-4.

GUO, et al. “Identification of a plant Nitric Oxide synthase gene involved in hormonal signaling.”
Science, 2003 Oct 3; 302(5642):100-3.

Del Rio, L., Corpas, F. and Barrosos, J. “Nitric Oxide and Nitric Oxide synthase activity in plants.”
Phytochemistry 2004 Apr; 65(7):783-92

Schaffer, et al. “Nitric Oxide regulates wound healing.”
J Surg Res. 1996; 63: 237-240

Taubert, et al. “Aspirin induces Nitric Oxide release from vascular endothelium: a novel mechanism of action.”
British Journal of Pharmacology 2004; 143: 159-165.

Hancock, C. and Riegger-Krugh, C. “Modulation of pain in osteoarthritis: the role of nitric oxide.”
Clin J Pain. 2008 May;24(4):353-65.

Jeschonneck, et al. “Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia.”
Rheumatology (Oxford). 2000; 39:917-921.

Akerstrom, et al.,“Nitric Oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.”
Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control. J Virol. 2005 Feb;79(3):1966-9.

Nitric oxide: From menace to marvel of the decade

Reproductive and Cardiovascular Disease Research Group

Arthritis Research & Therapy
arthritis research

UC Irvine researchers reveal structure of molecule that regulates blood pressure

The Building Blocks of Erection: Nitric Oxide . . . and More Nitric Oxide

Spiraling high blood pressure linked to Nitric Oxide deficiency



Study Points to Role of Nitric Oxide in New Treatments for Sickle Cell Anemia

Cortical feedback to the thalamus is selectively enhanced by nitric oxide.

Nitric Oxide Deficiency Raises Cardiovascular Disease Risk in African Americans

Study: Nitric Oxide Key to Brain ‘Booting Up’

Heart Disease Risk Factor #1: Nitric Oxide

Nitric Oxide Converted in the Stomach
McKnight, G.M., et al., “Chemical synthesis of Nitric Oxide in the stomach from dietary nitrate in humans.”
Gut. 1997; 40: 211-4.

Nitric Oxide and the Blood
“Duke researchers discover central role of Nitric Oxide in hemoglobin action.”
Duke Medicine News and Communication. 3 Nov. 2004.

Gladwin, M., et al. “Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.”
Proc Natl Acad Sci U S A. 2000 Oct. 10; 97(21): 11482-7.

Blood flow and Alzheimer’s
Mazza, M., et al., “Primary cerebral blood flow deficiency and Alzheimer’s disease: shadows and lights.”
J Alzheimers Dis. 2011 Jan 1;23(3):375-89.

Bone Health
Health News Report “Exercise and Vitamin D Help Prevent Falls in Seniors.”
2010 Dec 23.

Nazrun, A.S., M. Norazlina, M. Norliza and S.I. Nirwana, 2011. Tocotrienols as an anti-osteoporotic agent: The progress so far. Int. J. Osteoporosis Metab. Disorders, 1: 1-14.

“Nitric oxide: novel therapy for osteoporosis.”
Expert Opin Pharmacother. 2008 Dec;9(17):3025-44.

Nitric Oxide and Recovery
Diwan, A., et al.“Nitric Oxide modulates fracture healing.”
J Bone Miner Res. 2000 Feb;15(2):342-51.



  • The extract of Kyäni’s proprietary noni blend was tested at two concentrations in the presence and the absence of Vascular Endothelial Growth Factor (VEGF) for its ability to inhibit angiogenesis using the aortic ring model.
  • The rings treated with VEGF alone exhibited growth of the microvessels over the 7 days of the investigation.
  • At no one point of time was any microvessel growth observed when the aortic rings were cultured in the presence of two different concentrations of Kyäni’s proprietary noni blend extract.
  • Furthermore the two concentrations of noni blend also completely prevented any vessel growth in rings treated with VEGF.